VEGFB/VEGFR1-Induced Expansion of Adipose Vasculature Counteracts Obesity and Related Metabolic Complications
نویسندگان
چکیده
منابع مشابه
Obesity-Related Metabolic Syndrome and Vascular Complications
The epidemic of obesity, a condition defined as a body mass index (BMI) of 30.0 or more, has spread beyond the borders of high-income countries and is now dramatically on the rise also in low-and middle-income nations, particularly in urban settings [1]. One of the most concerning implications of this trend is the association between obesity and an increased risk of developing metabolic and car...
متن کاملDifferential Role of Adipose Tissues in Obesity and Related Metabolic and Vascular Complications
This review focuses on the contribution of white, brown, and perivascular adipose tissues to the pathophysiology of obesity and its associated metabolic and vascular complications. Weight gain in obesity generates excess of fat, usually visceral fat, and activates the inflammatory response in the adipocytes and then in other tissues such as liver. Therefore, low systemic inflammation responsibl...
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Adipose tissue dysfunction plays a pivotal role in the development of insulin resistance in obese individuals. Cell culture studies and gain-of-function mouse models suggest that canonical Wnt proteins modulate adipose tissue expansion. However, no genetic evidence supports a role for endogenous Wnt proteins in adipose tissue dysfunction, and the role of noncanonical Wnt signaling remains large...
متن کاملLiraglutide counteracts obesity and glucose intolerance in a mouse model of glucocorticoid-induced metabolic syndrome
BACKGROUND Glucocorticoid excess is commonly associated with diabetogenic effects, including insulin resistance and glucose intolerance. The effects of the long-term glucagon-like peptide 1 receptor agonist treatment on the metabolic syndrome-like conditions are not yet fully elucidated. Thus, we aimed to test whether long-term liraglutide treatment could be effective as a therapy to counteract...
متن کاملTargeting adipose tissue inflammation to treat the underlying basis of the metabolic complications of obesity.
The prevalence of obesity has increased throughout the last three decades due to genetic, metabolic, behavioral, and environmental factors [1]. Obesity in turn increases risk for a number of metabolic diseases including type 2 diabetes, cardiovascular disease, fatty liver disease and some forms of cancer [1]. Despite the well-known link between obesity and increased morbidity, the mechanism of ...
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ژورنال
عنوان ژورنال: Cell Metabolism
سال: 2016
ISSN: 1550-4131
DOI: 10.1016/j.cmet.2016.03.004